NAPLEX Blueprint

The NAPLEX Competency Statements provide a blueprint of the topics covered on the examination. They offer important information about the knowledge, judgment, and skills you are expected to demonstrate as an entry-level pharmacist. A strong understanding of the Competency Statements will aid in your preparation to take the examination.

Competency Statements

Area 1 Assess Pharmacotherapy to Assure Safe and Effective Therapeutic Outcomes (Approximately 56% of Test)

  • 1.1.0 Identify, interpret, and evaluate patient information to determine the presence of a disease or medical condition, assess the need for treatment and/or referral, and identify patient-specific factors that affect health, pharmacotherapy, and/or disease management.
  • 1.1.1 Identify and assess patient information including medication, laboratory, and disease state histories.
  • 1.1.2 Identify patient specific assessment and diagnostic methods, instruments, and techniques and interpret their results.
  • 1.1.3 Identify and define the etiology, terminology, signs, and symptoms associated with diseases and medical conditions and their causes and determine if medical referral is necessary.
  • 1.1.4 Identify and evaluate patient genetic, and biosocial factors, and concurrent drug therapy, relevant to the maintenance of wellness and the prevention or treatment of a disease or medical condition.
  • 1.2.0 Evaluate information about pharmacoeconomic factors, dosing regimen, dosage forms, delivery systems and routes of administration to identify and select optimal pharmacotherapeutic agents, for patients
  • 1.2.1 Identify specific uses and indications for drug products and recommend drugs of choice for specific diseases or medical conditions.
  • 1.2.2 Identify the chemical/pharmacologic classes of therapeutic agents and describe their known or postulated sites and mechanisms of action.
  • 1.2.3 Evaluate drug therapy for the presence of pharmacotherapeutic duplications and interactions with other drugs, food, and diagnostic tests.
  • 1.2.4 Identify and evaluate potential contraindications and provide information about warnings and precautions associated with a drug product’s active and inactive ingredients.
  • 1.2.5 Identify physicochemical properties of drug substances that affect their solubility, pharmacodynamic and pharmacokinetic properties, pharmacologic actions, and stability.
  • 1.2.6 Evaluate and interpret pharmacodynamic and pharmacokinetic principles to calculate and determine appropriate drug dosing regimens.
  • 1.2.7 Identify appropriate routes of administration, dosage forms, and pharmaceutical characteristics of drug dosage forms and delivery systems, to assure bioavailability and enhance therapeutic efficacy.
  • 1.3.0 Evaluate and manage drug regimens by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education to enhance safe, effective, and economic patient outcomes.
  • 1.3.1 Identify pharmacotherapeutic outcomes and endpoints.
  • 1.3.2 Evaluate patient signs and symptoms, and the findings of monitoring tests and procedures to determine the safety and effectiveness of pharmacotherapy. Recommend needed followup evaluations or tests when appropriate.
  • 1.3.3 Identify, describe, and provide information regarding the mechanism of adverse reactions, allergies, side effects, iatrogenic, and drug-induced illness, including their management and prevention.
  • 1.3.4 Identify, prevent, and address methods to remedy medication non-adherence, misuse, or abuse.
  • 1.3.5 Evaluate current drug regimens and recommend pharmacotherapeutic alternatives or modifications.

Area 2 Assess Safe and Accurate Preparation and Dispensing of Medications (Approximately 33% of Test)

  • 2.1.0 Demonstrate the ability to perform calculations required to compound, dispense, and administer medication.
  • 2.1.1 Calculate the quantity of medication to be compounded or dispensed; reduce and enlarge formulation quantities and calculate the quantity or ingredients needed to compound the proper amount of the preparation.
  • 2.1.2 Calculate nutritional needs and the caloric content of nutrient sources.
  • 2.1.3 Calculate the rate of drug administration.
  • 2.1.4 Calculate or convert drug concentrations, ratio strengths, and/or extent of ionization.
  • 2.2.0 Demonstrate the ability to select and dispense medications in a manner that promotes safe and effective use.
  • 2.2.1 Identify drug products by their generic, brand, and/or common names.
  • 2.2.2 Identify whether a particular drug dosage strength or dosage form is commercially available and whether it is available on a nonprescription basis.
  • 2.2.3 Identify commercially available drug products by their characteristic physical attributes.
  • 2.2.4 Assess pharmacokinetic parameters and quality assurance data to determine equivalence among manufactured drug products, and identify products for which documented evidence of inequivalence exists.
  • 2.2.5 Identify and provide information regarding appropriate packaging, storage, handling, administration, and disposal of medications.
  • 2.2.6 Identify and provide information regarding the appropriate use of equipment and apparatus required to administer medications.
  • 2.3.0 Demonstrate the knowledge to prepare and compound extemporaneous preparations and sterile products.
  • 2.3.1 Identify techniques, procedures, and equipment related to drug preparation, compounding, and quality assurance.
  • 2.3.2 Identify the important physicochemical properties of a preparation’s active and inactive ingredients.
  • 2.3.3 Identify the mechanism of and evidence for the incompatibility or degradation of a product or preparation and methods for achieving its stability.

Area 3 Assess, Recommend, and Provide Health care Information that Promotes Public Health (Approximately 11% of Test)

  • 3.1.0 Identify, evaluate, and apply information to promote optimal health care.
  • 3.1.1 Identify the typical content of specific sources of drug and health information for both health care providers and consumers, and recommend appropriate resources to address questions or needs.
  • 3.1.2 Evaluate the suitability, accuracy, and reliability of clinical and pharmacoeconomic data by analyzing experimental design, statistical tests, interpreting results, and formulating conclusions.
  • 3.2.0 Recommend and provide information to educate the public and healthcare professionals regarding medical conditions, wellness, dietary supplements, and medical devices.
  • 3.2.1 Recommend and provide health care information regarding the prevention and treatment of diseases and medical conditions, including emergency patient care and vaccinations.
  • 3.2.2 Recommend and provide health care information regarding nutrition, lifestyle, and other non-drug measures that promote health or prevent the progression of a disease or medical condition.
  • 3.2.3 Recommend and provide information regarding the documented uses, adverse effects, and toxicities of dietary supplements.
  • 3.2.4 Recommend and provide information regarding the selection, use, and care of medical/surgical appliances and devices, self-care products, and durable medical equipment, as well as products and techniques for self-monitoring of health status and medical conditions.