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NAPLEX Blueprint

The NAPLEX Competency Statements provide a blueprint of the topics covered on the examination. They offer important information about the knowledge, judgment, and skills you are expected to demonstrate as an entry-level pharmacist. A strong understanding of the Competency Statements will aid in your preparation to take the examination.

Competency Statements

AREA 1 – Ensure Safe and Effective Pharmacotherapy and Health Outcomes (Approximately 67% of Test)

1.1.0 Obtain, Interpret, Assess, and/or Evaluate:

  • 1.1.1 Information from patient interviews
  • 1.1.2 Patient medical records
  • 1.1.3 Results from instruments and screening strategies used to assess patients
  • 1.1.4 Laboratory and diagnostic findings
  • 1.1.5 Signs and symptoms associated with diseases and medical conditions
  • 1.1.6 Patients’ need for medical referral
  • 1.1.7 Risk factors relevant to the prevention of a disease or medical condition and the maintenance of wellness
  • 1.1.8 Information from interdisciplinary health care providers

1.2.0 Develop and Implement Individualized Treatment Plans, Taking Into Consideration:

  • 1.2.1 Specific uses and indications and dosing for drugs
  • 1.2.2 Purported uses and indications for dietary supplements and complementary and alternative medicine
  • 1.2.3 Lifestyle and self-care therapy
  • 1.2.4 Pharmacologic classes and characteristics of drugs
  • 1.2.5 Actions and mechanisms of actions of drugs
  • 1.2.6 The presence of pharmacotherapeutic duplications and/or omissions
  • 1.2.7 Drug interactions
  • 1.2.8 Contraindications, warnings, and precautions
  • 1.2.9 Allergies
  • 1.2.10 Adverse effects and drug-induced illness
  • 1.2.11 Pharmacodynamic, pharmacokinetic, and pharmacogenomic principles
  • 1.2.12 Pharmacokinetic data to determine equivalence among drug products
  • 1.2.13 Pharmacoeconomic factors
  • 1.2.14 Routes and methods of administration, dosage forms, and delivery systems

1.3.0 Assess and Modify Individualized Treatment Plans, Considering:

  • 1.3.1 Therapeutic goals and outcomes
  • 1.3.2 Safety of therapy
  • 1.3.3 Efficacy of therapy
  • 1.3.4 Medication non-adherence or misuse

1.4.0 Techniques for Effective Communication/Documentation of the Development, Implementation, and Assessment of Individualized Treatment Plans to:

  • 1.4.1 Patients and/or patients’ agents
  • 1.4.2 Interdisciplinary health care providers

1.5.0 Advocate Individual and Population-Based Health and Safety, Considering:

  • 1.5.1 Best practices, scientific literature evaluation, and health-related resources
  • 1.5.2 Quality improvement strategies in medication-use systems
  • 1.5.3 Processes, evaluation of, and responses regarding medication errors
  • 1.5.4 Role of automated systems and technology in medication distribution processes
  • 1.5.5 Emergency preparedness protocols

AREA 2 – Safe and Accurate Preparation, Compounding, Dispensing, and Administration of Medications and Provision of Health Care Products (Approximately 33% of Test)

2.1.0 Employ Various Techniques to Calculate:

  • 2.1.1 Patients’ nutritional needs and the content of nutrient sources
  • 2.1.2 Drug concentrations, ratio strengths, and/or extent of ionization
  • 2.1.3 Quantities of medication to be compounded, dispensed, or administered
  • 2.1.4 Quantities of ingredients needed to compound preparations
  • 2.1.5 Rates of administration

2.2.0 Compound Sterile and Nonsterile Products, Considering:

  • 2.2.1 Techniques, procedures, and equipment for drug preparation, compounding, and administration of sterile products
  • 2.2.2 Techniques, procedures, and equipment for drug preparation, compounding, and administration of nonsterile products
  • 2.2.3 Physicochemical properties of active and inactive ingredients
  • 2.2.4 Identifying the presence of, and the cause of, product incompatibilities or degradation and methods for achieving stability
  • 2.2.5 Physiochemical properties of drugs that affect solubility and stability

2.3.0 Review, Dispense, and Administer Drugs and Drug Products, Considering:

  • 2.3.1 Packaging, labeling, storage, handling, and disposal of medications
  • 2.3.2 Commercial availability, identification, and ingredients of prescription and non-prescription drugs
  • 2.3.3 Physical attributes of drug products
  • 2.3.4 Specific instructions and techniques for administration