FPGEE Blueprint

The FPGEE Competency Statements provide a blueprint of the topics covered on the examination. A strong understanding of the Competency Statements will aid in your preparation to take the examination.

In 2015, a committee of subject matter experts reviewed the statements and revised them to be consistent with entry-level doctor of pharmacy programs in the United States. The Competency Statements below will go into effect in April 2016. 

Competency Statements 

Area 1.0 – Basic Biomedical Sciences 10%

  • 1.1 Physiology
    • 1.1.1 Function of the major body systems and homeostatic impact at organ and system level 
  • 1.2 Biochemistry
    • 1.2.1 Chemistry and utilization of biomacromolecules including proteins, lipids, carbohydrates, nucleic acid, intermediary metabolism of energy and nutritional molecules
    • 1.2.2 Enzymology and coenzymes and kinetics
    • 1.2.3 Cell chemistry, signal transduction pathways
    • 1.2.4 Transport and mobility
    • 1.2.5 Recombinant DNA and molecular biotechnology
    • 1.2.6 mRNA translation and protein synthesis
  • 1.3 Microbiology Related to Human Disease
    • 1.3.1 Structure, function, and characteristics of microorganisms: microbe classification, structure, metabolism, genetics
    • 1.3.2 Pathogenic microorganisms of humans
  • 1.4 Immunology
    • 1.4.1 Innate and adaptive immunity
    • 1.4.2 Principles of antibody actions
    • 1.4.3 Hypersensitivity and types of reactions

Area 2.0 – Pharmaceutical Sciences 33%

  • 2.1 Medicinal Chemistry
    • 2.1.1 Physicochemical properties of drugs in relation to drug absorption, distribution, metabolism, and excretion (ADME)
    • 2.1.2 Chemical basis for drug action
    • 2.1.3 Fundamental pharmacophores for drugs used to treat diseases
    • 2.1.4 Structure-activity relationships in relation to drug-target interactions
    • 2.1.5 Chemical pathways of drug metabolism
    • 2.1.6 Applicability to making drug therapy decisions
  • 2.2 Pharmacology and Toxicology
    • 2.2.1 Mechanisms of action of drugs of various categories including biologics
    • 2.2.2 Pharmacodynamics of drug binding and response
    • 2.2.3 Adverse effects and side effects of drugs
    • 2.2.4 Mechanisms of drug-drug interactions
    • 2.2.5 Drug discovery and development
    • 2.2.6 Acute and chronic toxic effect of xenobiotics, including drug and chemical overdose and antidotes
  • 2.3 Pharmacognosy and Dietary Supplements
    • 2.3.1 Concepts of crude drugs, semi-purified, and purified natural products
    • 2.3.2 Classes of pharmacologically active natural products
    • 2.3.3 Science and regulation of dietary supplements (vitamins, minerals, and herbals)
  • 2.4 Pharmaceutics/Biopharmaceutics
    • 2.4.1 Biopharmaceutical principles of drug delivery to the body via dosage forms: liquid, solid, semisolid, controlled release, patches, implants
    • 2.4.2 Materials and methods used in preparation of drug forms
    • 2.4.3 Physicochemical properties relating to drug entities and dosage forms
    • 2.4.4 Principles of drug and dosage form stability, including chemical degradation and physical instability
  • 2.5 Pharmacokinetics
    • 2.5.1 Basic principles of in-vivo drug kinetics (linear and nonlinear)
    • 2.5.2 Principles of bioavailability and bioequivalence
    • 2.5.3 Physiologic determinates of drug onset and duration, including disease and dietary influences on absorption, distribution, metabolism, and excretion
  • 2.6 Pharmacogenomics and Genetics
    • 2.6.1 Molecular genetics, genomic, proteomic, and metabolomic principles that serve as a foundation for pharmacogenomics and the genetic basis of disease
    • 2.6.2 Genetic variants affecting drug action and metabolism, adverse drug reactions, and disease risk that influence the practice of personalized medicine
  • 2.7 Sterile and Nonsterile Compounding
    • 2.7.1 United States Pharmacopeia guidelines on sterile and nonsterile compounding, hazardous drugs, and FDA regulation of compounding
    • 2.7.2 Techniques and principles used to prepare and dispense individual extemporaneous prescriptions, including dating of compounded dosage forms
    • 2.7.3 Dosage form preparation calculations
    • 2.7.4 Sterile admixture techniques, including stability, clean-room requirements, sterility testing, and dating

Area 3.0 – Social/Behavioral/Administrative Sciences 22%

  • 3.1 Health Care Delivery Systems and Public Health
    • 3.1.1 Organization of health care delivery systems at the national, state, and local levels: various settings where pharmacy is practiced and the structure of health care delivery systems such as managed care organizations, accountable care organizations, health departments 
    • 3.1.2 Health care delivery financing in the United States
    • 3.1.3 Social, political, and economic factors that influence the delivery of health care in the United States
    • 3.1.4 Public Health and Wellness: chronic disease prevention, health promotion, infectious disease control, demographics, physical, social, and environmental factors leading to disease, comparing and contrasting public health with individual medical care
    • 3.1.5 The health care delivery system compared and contrasted with that of other industrialized nations
  • 3.2 Population-Based Care and Pharmacoepidemiology
    • 3.2.1 Data sources and analytic tools that provide an estimate of the probability of beneficial or adverse effects of medication use in large populations
    • 3.2.2 Application of epidemiological study designs to evaluate drug use and outcomes in large populations
    • 3.2.3 Methods for continually monitoring unwanted effects and other safety-related aspects of medication use in large populations
  • 3.3 Economic and Humanistic Outcomes of Health Care Delivery
    • 3.3.1 General microeconomic and general macroeconomic principles
    • 3.3.2 Pharmacoeconomic analysis and its application to improve the allocation of limited health care resources
    • 3.3.3 Humanistic outcomes and their application to improve the allocation of limited health care resources
  • 3.4 Pharmacy Practice Management
    • 3.4.1 Management principles (planning, organizing, directing, and controlling pharmacy resources) applied to various pharmacy practice setting and patient outcomes
    • 3.4.2 Personnel management
    • 3.4.3 Planning, including delineation between business and strategic planning
    • 3.4.4 Marketing of goods and services: product versus service pricing, distribution, promotion
    • 3.4.5 Accounting and financial management
    • 3.4.6 Budgeting
    • 3.4.7 Risk management
  • 3.5 Pharmacy Law and Regulatory Affairs
    • 3.5.1 Legal and regulatory principles applied to pharmacy practice: dispensing, professional services, drug use control
    • 3.5.2 Administrative, civil, and criminal liability
    • 3.5.3 Authority, responsibilities, and operation of agencies and entities that promulgate or administer laws, regulations, or guidances related to practice and prescription and nonprescription medications
  • 3.6 Biostatistics and Research Design
    • 3.6.1 Research study designs used in medical research
    • 3.6.2 Application and interpretation of statistical tests and data collection instruments
  • 3.7 Ethical Decision Making
    • 3.7.1 Principles of biomedical ethics
    • 3.7.2 Ethical dilemmas in the delivery of patient, centered care including, conflicts of interest, end-of-life decision making, use of codes of ethics, oaths of the pharmacist
    • 3.7.3 Research ethics
  • 3.8 Professional Communication
    • 3.8.1 Communication abilities (appropriate verbal, nonverbal, visual, and written) with patient and caregivers, including empathetic communication
    • 3.8.2 Communication abilities with other health care providers
    • 3.8.3 Assertiveness and problem-solving techniques in relation to difficult social and professional conflicts and situations
    • 3.8.4 Measurement and use of health literacy in pharmacy communications
    • 3.8.5 Development of cultural competency in pharmacy personnel such that services are respectful of and responsive to the health beliefs, practices, and cultural and linguistic needs of diverse patient populations
  • 3.9 Social and Behavioral Aspects of Pharmacy Practice
    • 3.9.1 Health-, illness-, and sick-role behaviors of patients
    • 3.9.2 Principles of behavior modification
    • 3.9.3 Patient adherence to therapies and recommendations
    • 3.9.4 Caregiving throughout the lifecycle
    • 3.9.5 Death and dying
  • 3.10 Medication Dispensing and Distribution Systems
  • 3.10.1 Systems for safe and effective preparation and dispensing of medications in all types of practice settings
  • 3.10.2 Role of automation and technology: pharmacy informatics, information management
  • 3.10.3 Continuous quality improvement programs or protocols in the medication-use process, including identification and prevention of medication errors, and establishment of error reduction programs

Area 4.0 – Clinical Sciences 35%

  • 4.1 Evidence-based Practice
    • 4.1.1 Interpret and evaluate drug information
    • 4.1.2 Apply drug-information skills for the delivery of medication therapy management
    • 4.1.3 Evaluate the reliability of various sources of information
    • 4.1.4 Interpret guidelines as they apply in a clinical setting
    • 4.1.5 Utilize core scientific and systems-based knowledge in the patient care decision-making process
    • 4.1.6 Utilize basic science principles in the development and/or implementation of drug treatment protocols and clinical practice guidelines
    • 4.1.7 Evaluate clinical trials that validate clinical appropriateness
  • 4.2 Clinical Pathophysiology
    • 4.2.1 Apply concepts of pathophysiology to clinical decision making 
  • 4.3 Clinical Pharmacokinetics
    • 4.3.1 Utilize pharmacokinetics to calculate, evaluate, and individualize drug therapy
    • 4.3.2 Interpret clinical pharmacokinetics of commonly used and low-therapeutic-index drugs
  • 4.4 Clinical Pharmacogenomics
    • 4.4.1 Utilize pharmacogenomics to calculate, evaluate, and individualize drug therapy
  • 4.5 Disease Prevention and Population Health
    • 4.5.1 Recognize the proper use of nonpharmacologic therapies, including complementary and alternative medicines
    • 4.5.2 Describe measures to promote wellness and disease prevention
    • 4.5.3 Identify the role of immunizations in disease prevention and health promotion
  • 4.6 Patient Assessment 
    • 4.6.1 Describe techniques for obtaining a comprehensive patient history
    • 4.6.2 Describe how to perform patient physical assessments: inspection, palpation, percussion, auscultation
    • 4.6.3 Differentiate between normal physical assessment findings and modifications caused by common disease states and drug therapy
    • 4.6.4 Interpret common clinical laboratory values and diagnostic tests
    • 4.6.5 Perform calculations related to patient assessment: BMI, CrCl, lab adjustments
    • 4.6.6 Describe the use of OTC point-of-care testing devices: glucometers, pregnancy tests, home testing for HbA1c, drug screening
  • 4.7 Clinical Pharmacology and Therapeutic Decision Making 
    • 4.7.1 Make therapy recommendations based on dosage calculations, specific uses and indications of drugs and nutritional and support therapy
    • 4.7.2 Interpret therapeutic drug concentrations
    • 4.7.3 Assess pharmacotherapy considering contraindications, therapeutic duplications, dietary interactions, adverse drug reactions and interactions, and allergies
    • 4.7.4 Triage and identify when to refer patients to other health professionals
    • 4.7.5 Design patient-centered, culturally-relevant treatment plans
    • 4.7.6 Apply evidence-based decision making to patient care
    • 4.7.7 Recommend nonprescription and natural product therapies
    • 4.7.8 Identify and manage drug toxicity, drug-induced diseases, and misuse or abuse
    • 4.7.9 Monitor drug therapy for misuse, abuse, and non-adherence